An ophthalmologist asks to make eye drops with the active ingredient: azithromycin, cefuroxime, or ceftriaxone. The concentration is not specified and in the Martendale I do not find anything back.

I prefer cefuroxime, which is recovered as sodium salt in the specialtés Zinacef and Claforan. The powder, which, after dissolving, is intended for injection, is now dissolved in either sterile water for injections or sterile physiological serum. The concentration for eye drops is 5 or 5.5%. A bottle of Claforan contains 1050mg Na-cefuroxime and consequently 2 vials of 10ml of eye drops can be prepared, each containing 525mg product (= 500mg cefuroxime). Since the whole process "aseptic" should be done with sterilized devices, it is appropriate to prepare two eye dropbottles. This should not be weighed and the vial Claforan has been fully reworked. Research shows that stability in a buffered solution does not improve as in physiological serum. Kept at room temperature The shelf life is very short. When storing in the refrigerator we can count on a shelf life of 21 days. In the refrigerator this 12 months. From a practical point of view, this last method of detention is not interesting for the user. But whoever has a bottle in stock should therefore keep it in the freezer compartment of the refrigerator.