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Question

Posted on: November 2 2015

Preparation Egg Prednisolon 100mg.

You need a large amount of active product that is very electrostatically charged. Preparation in egg NR3 there is not even a filler required. How do you prepare these egg?

Answer

There are several proposals to make, which can help to solve your problem. I sum them up without being able to offer you the certainty that they can solve the cited problem in their own right. Perhaps a number of things need to be combined.  

1. The use of plastic materials is certainly not advantageous for the presence of electrostatic charges. The mortar we can easily replace with a round inox bowl. The upper plate of the capsulevulapparaate, where the powder is applied to, is usually made of plastic. Capsulevulapparates such as the ones, which you can find via the following link, are recommended for such preparation   (but also for many others), since they are made entirely out of stainless steel. The use of Inox has a large number of advantages also on the faultless operation.

http://www.qualenica.be/machines/profiller%C2%AE-capsule-vulsystemen

2. Another important point is the humidity. It may be recommended to allow the prednisolone powder to be equilibrate for 1 night in an environment with a relative humidity of 45 to 60%. The lack of an exsicatorvat is not the biggest problem here. It can be circumvented but for the preparation of the saline solution, which is poured at the bottom of the barrel, must be invoked on a non-daily salt.  

3. Addition of a powder, which is able to derive electrical loads, is necessary. Therefore, we recommend using the following filler to replenish the volume of your mass prednisolone to the volume necessary for filling in hard gelatine capsules N ° 0 (zero)

R/  calcium Monohydrogen phosphate 2 aq 94 g; Primojel (after Carboxymethylstarch A) or possibly Starch 5 G and Coll Alumina 1 G  

Pharmacists, who are not in favour of the use of lactose as filler, have cellulose microcrystalline (Avicel ph101, 102?) in stock. Maybe you too? Perhaps this may take the place of   calcium monohydrogen phosphate 2 aq????