Question
Posted on: March 6 2013Problems with a prescription for Tretinoin 0.05% in Cremor non ionicus oleosus.
The composition of cremor non-Ionicus oleosus is as follows:
R/Cera alba 6gI mix the required amount of Trentino ï NE Concentrate with the ex tempore prepared Cremor non ion oleosus. Sometimes it decomposes the CR è me-there is water running out. What can be the cause and how do I fix it?
Cetaceum 5g
Cera Liquida (Cetiol V) 31g
Span 80 2g
Arlacel C 8g
Aqua conservans 48g
the composition of the hydrophilic Tretino ï NE Concentrate 2% is: Tretino ï ne 250mg and hydrophilic concentrate base 12.25 g
The composition of the hydrophilic concentrate base: cetostearyl alcohol 30g; Butylhydroxytolua 40mg and Propylene glycol ad 100g.
a small proportion of the hydrophilic concentrate base is brought into mortar; the necessary amount of Tretino ï ne is attached; we mix gently and add a hydrophilic concentrate base until all the base is used up. Three times through the ointment mill. This concentrate is filled in an ointment tube and lasts for six months in the refrigerator.
Answer
Given the composition of the Cremor non-ionicus oleosus I would choose a lipophilic concentrate. With this lipophilic concentrate base, one can prepare a lipophilic tretino ï NE 2% concentrate.
the composition of the lipophilic concentrate base is: BHT 40mg; white petroleum jelly up to 100g
mixing with the Cremor non-Ionicus oleosus will have to be done while the latter is still hot liquid.
the composition of the lipophilic concentrate base is: BHT 40mg; white petroleum jelly up to 100g
mixing with the Cremor non-Ionicus oleosus will have to be done while the latter is still hot liquid.