Question by Dermatologe: Salicylic acid 10% in Efudix: Does the cream remain stable? Do the active ingredients remain stable?

In a previous reply, the discoloration was attributed to a reaction of salicylic acid with e.g. Fe ions and therefore the proposal EDTA Insert. You ask yourself questions about the stability of the active ingredient.   But 5-fluouracil is quite stable in acidic solutions = salicylic acid; and is very little soluble in water. So.............................. ..........   Verrumal also contains 5-fluouracil but I can say if the doctor wants to switch to Verrumal with addition of salicylic acid, Try and see if there is any discoloration whatsoever. One never knows.