We have a patient who needs gastric acid inhibitors. However, he is unable to take medication orally. We would like to process ranitidine 300mg or Omeprazole 20 mg in Suppos.

If we limit ourselves to suppositories, then only about Omeprazole can find an article, which will help you on the road.

Rectal Absorption of omeprazole from suppository in humans.

Choi MS, Chung SJ, Shim CK.

College of Pharmacy, Seoul National University, Korea.

The Oral absorption of omeprazole is incomplete, in part due to first-pass metabolism. We investigated the feasibility of rectal administration of omeprazole by comparing its absorption from a Witepsol H15-based rectal suppository and an orally administered commercial gelatin capsule in 10 male volunteers. Profiles of plasma concentration between two preparations (20 mg) were not significant different, indicating that the rate and the extent of absorption were similar. Paired T-Test revealed no significant differences in area under the curve, mean residence time, and time to peak concentration between two preparations. On the other hand, lag time of absorption and peak concentration were significant different (p about the rectal absorption of ranitidine, a study was Carried out at the University of Leiden. However, the researchers used an osmotic pump (OsmoMet) that ensures continuous constant relief. Now the authors of the article report that this system gives a faster absorption and this will happen slower from suppositories e.g. after half to 1 hour. Difference that we probably also find in the publication about Omeprazole. So also ranitidine can be administered via suppositories.