Question
Posted on: April 8 2014We have problems with the preparation of a testosterone gel.
Answer
The switching calibration of oleic acid to IPM is acceptable but why HPC is abandoned for Carbopol is not clear to me and seems to me not ideal because a good carbopolgel with a high ethanol content preparation is not easy. Although I opt for the top of IPM on the Carbopol gel earlier. As Thiss presumably is also the case when you add IPM to your original formula with HPC.
Personally I would opt for the use of Octyldodecanol (Eutanol) instead of IPM.
Following composition I found in the literature: Octyldodecanol 18 G, isopropanol 69 g and Water ad 100 g. This composition may serve as a starting point and you can modify it to approximate your original formula. You can take the Eutanol at 10 g, replace the isopropanol with ethanol and possibly bring more water.
I would first run some previews like eg
1. Dissolve 10 g Eutanol in 69 g ethanol and add water up to 100 g. You should not obtain a separation of the Eutanol!
2. In this mixture the testosterone should dissolve
3. And this mixture can convert you to a gel with HPC
Succeeds all this then you can unsubscribe the final composition. If an additional constituent is testosterone or HPC added is getting these amounts in deduction of water.