Question
Posted on: March 6 2013A recent number of Folia describes a magistal preparation with peppermint oil as a possible treatment for irritable bowel syndrome.
How we bring 0.2 ml of peppermint oil (per capsule) into capsules. We wanted to rub this with lactose dry, but this does not succeed us. On KAVA they had said to do this with starch and aerosil. Do you have a better solution or the right proportions of starch and aerosil?
Answer
I think most simple method consists in the amount of ML & #039; s to count in a number of drops and bring this number of drops in each capsule. Then the capsules are filled with an absorbent filler. After closure, the capsules are provided with a gastric juice-resistant coating as prescribed.
Modus Operandi
- Calibration of used drip counter
take a pipette and fill them with mint oil. Then place a beaker on a balance and tarreer. Then count the number of drops needed to weigh 1g peppermint oil. Note this value. - Conversion of a volumetric amount of mint oil into a number of drops
the density of mint oil is 0.91; so 0.2 ml = 0.182 g or 182mg and 0.4 ml = 364mg. Suppose the used droplet counter gives 50 drops for 1. g Mint oil then weighs 1 drop of 20mg and comes 182mg corresponding to 9 drops. - Preparation of the filler for the capsules (composition communicated by Apoth. Deepak
Bring in a mortar 3g Aerosil, add 2g silicon dioxide precipitated and mix to homogenous. Add in fractions 25g wheat starch. - Preparation of the capsules
Place the number of capsules to be prepared in the capsulevulapparate and remove the cups. In each capsule, apply the calculated number of droplets of mint oil using the calibrated eyedropper. Then fill the capsules with the prepared filler. Close the capsules firmly and proceed to apply a gastric juice resistant coating.