Question
Posted on: March 6 2013How can I handle vitamin A acetate in the buccal solution? Lidocaine. HCl 500.0 mg Tetracycline. HCl 1.0 g Vitamin A acetate 500.0 mg single syrup 30.0 g
Aqua Conservans AD 100 ml < BR/> On the one hand, vitamin A is incompatible with acids and on the other hand insoluble in water.
Answer
- the stability of tetracycline and
- the insolubility of vitamin A acetate.
problem 1
dissolved condition decomposes tetracycline and after a few days you have a Brown-Black colored solution. TetracyclineHCl should be converted to tetracycline base and here this can be using lidocaine as at least the base form used instead of the hydrochloride. The whole becomes a suspension!
problem 2
The powder Vit A acetate (250,000 U.I.) We can best replace it with Vit A acetate water soluble (2.5 ml). I suspect that the required amount of solubilizer is provided in this product. If this product Is no longer available, it should be solubilised with e.g. Tween 80 (Tween 80/Oil ratio, 8:1). The flavour is not optimal, but it is not excluded that the amount of Tween 80 can be reduced by the presence of Sirupus simplex.
you make remarks about the stability of Vit A. Rightly so. Maybe once the pH measurement of the whole? Now we can hope that solubilized Vit A is more stable.