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Question

Posted on: March 6 2013

An injection of sodium perchlorate.

Is it possible to make a preparation for IV administration of sodium perchlorate? Are preparation data, stability,... Known? Product should be used in a 4-week baby for thyroid protection in radiotherapeutic studies. The dose should be approximately 100mg.

Answer

R/naperchlorate 2g
Water for injections up to 100ml
A cooking method I can not find Ttz I do not know if the solution may be autoclaved. So this becomes temporary sterile filtration. Stability does not seem to pose a problem according to the reference below.

Stability of aqueous perchlorate formulations
CC Williams

The Stability of three aqueous perchlorate formulations used in nuclear medicine was studied as a function of The formulation and storage temperature. The formulations were intravenous potassium perchlorate solution, oral sodium perchlorate-sorbitol solution and oral potassium perchlorate in cherry syrup solution. The asses were conducted gravimetrically by precipitation with tetra-n-Pentylammonium bromide. All formulations were found to be stable at least nine months. It is recommended that any formulation containing potassium perchlorate be kept at room temperature since precipitation of the active ingredient may occur if refrigerated. Sodium perchlorate formulations, however, may be refrigerated if desired because of their greater solubility.