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Question

Posted on: March 6 2013

Next intricate composition for a W/O cream gives problems: Burowwater 5g chlorbutol 5g Cu sulfate 10mg Zn sulfate 200mg bacitracin 50000IU Methylprednisolone

160mg
Dexamethasone 80mg
betamethasone edipropionate 10mg
Arlacel 6g
Vaseline 54g
Water ad 100g < BR/> The CR è me is not stable and a grey discoloration of the CR è me occurs. Can this discoloration be avoided Be? Could the discoloration be caused by the formation of Znbacitracin?

Answer

We do not have a pass and ready answer to this question. It is clear that more research is needed by making some creams with different combinations of the raw materials. Then determine if a gray colouring occurs. I think the cortisones can be ruled out.

the basis of the problem is of course poly-medication, of which this regulation is a typical example. Many will react with the remark that such composition is no longer at home in modern medicine. I see a combination of metallic salts with Cortico & #039; s. And then another cocktail of Cortico & #039; s of which I do not know whether they are all ideal for dermatological practice.
your suggestion is not negligible!