Question
Posted on: March 6 2013Precipitate of salicylic acid in following preparation: Clobetasolpropionate 15mg Salicylic Acid 2.4 G Klucel GF 1.8 g propylene glycol 18ml aqua dest. 15ml F. Gel
used Preparation method: Dissolve salicylic acid and clobetasolpropionate in propylene glycol (clear solution). To rub the klucel with this solution in mortar. This gives a fairly homogeneous clear somewhat fishkeuzer mixture. When adding the water the mixture is returned less viscous and becomes white colored and less homogeneous.
Is The concentration of salicylic acid too high for this preparation and stores salicylic acid when adding water? If so, how much salicylic acid can be processed in this gel?