Vraag
Gepost op: 23 april 2014hoe kunnen we beclomethasone dipropionaat orale oplossing maken?
Antwoord
ik stuur hierbij een samnstelling op basis van maisolie. Blijkbaar heeft maisolie een beetje een speciale smaak en zou misschien beter zonnebloemolie worden gebruikt, die neutraler is van smaak. Hopelijk blijft de oplosbaarheid dezelfde.
Als smaakcorrigens zou u kunnen gebruik maken van anijsolie of kaneelolie. Misscien is vloeibare chocolade ook te verwerken onder de olie.
|
Drug Name |
Route |
Dosage Form |
Concentrationl |
|
Beclomethasone Dipropionate in Corn Oil |
Oral |
Solution - suspension |
1mg/ml |
Formula Qty: 120 mL Shelf Life: 180 days
Equipment needed:
Scale, mortar, pestle, graduated beaker, stirring rod
Auxiliary labeling/Storage: Room temperature
Directions:
1. Weigh out powder and triturate to a fine powder in mortar.
2. Begin to incorporate corn oil, small amounts at a time, mixing well after each addition.
3. Pour into beaker when all powder is incorporated.
4. Rinse mortar with additional corn oil, adding rinse to the beaker.
5. QS to final volume with corn oil.
6. Stir emulsion periodically with stirring rod for several hours until powder is dissolved and
emulsion is clear.
|
Ingredients |
QS |
Quantity |
Units |
|
Beclomethasone Dipropionate powder USP |
|
120 |
Mg |
|
Corn Oil |
X |
120 |
mL |
|
|
|
|
|
|
Citations/References |
|
1. Diez-Campelo M, Perez-Simon JA, Castilla C, et al. Oral Beclomethasone dipropionate for the treatment of GI acute graft versus host disease. Biology of Blood and Bone Marrow Transplantation. 2006; 12 (Feb):36. |
|
2. Iyer RV, Hahn T, Roy HN, et al. Long term use of oral beclomethasone dipropionate for the treatment of GI graft-versus-host disease. Biology of Blood and Marrow Transplantation. 2005; 11, 587-592. |
|
3. Nationwide Children’s Hospital, Seattle Cancer Care Alliance, and University of Washington MC/Drug
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