Kan men suppo's bereiden uitgaande van Trileptal tabletten?

De eerste vraag die we moeten stellen luidt: "is er rectale opname van het actief bestanddeel?"

De literatuur vermeldt twee artikelen, die dit sterk in twijfel trekken.

1. Relative bioavailability, metabolism and tolerability of rectally administered oxcarbazepine suspension.

   CONCLUSIONS: Monohydroxy derivative bioavailability following rectal administration of oxcarbazepine suspension is significantly lower than following oral administration, most likely because of poor oxcarbazepine water solubility. It is unlikely that adequate monohydroxy derivative concentrations can be achieved with rectal administration of diluted oxcarbazepine suspension.

2. Rectal absorption of oxcarbazepine, van der Kuy PH, Koppejan EH, Wirtz JJ. Laurentius Hospital, Roermond, The Netherlands.

   Physicians regularly challenge the hospital pharmacy departments to find alternative routes for the administration of drugs, which can't be withhold, e.g. anti-epileptic drugs. In our hospital we were confronted with the question whether it was possible to administer oxcarbazepine rectally. In the present report data on the absorption of rectally administered oxcarbazepine is presented. No therapeutic bloodlevels were attained after rectal administration. Administration via the oral route, however, gave within the same period of time a therapeutic bloodlevel. It is concluded that the absorption after rectal administration of oxcarbazepine at least in this dose and frequency used is too low to justify application in practice.